Lab Publications
Rodríguez, I.; Fernández-Vega, L.; Maser-Figueroa, A.N.; Sang, B.; González-Pagán, P.; Tinoco, A.D.* “Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds.” Antibiotics 2022, 11, 158. https://doi.org/10.3390/antibiotics11020158
Delinois, L.J.; De Leon-Velez, O.; Vazquez-Medina, A.; Velez-Cabrera, A.; Marrero-Sanchez, A.; Nieves-Escobar, C.; Alfonso-Cano, D.; Caraballo-Rodriguez, D.; Rodriguez-Ortiz, J.; Acosta-Mercado, J.; Benjamin-Rivera, J.A.; Gonzalez-Gonzalez, K.; Fernandez-Adorno, K.; Santiago-Pagan, L.; Delgado-Vergara, R.; Torres-Avila, X.; Maser-Figueroa, A.; Grajales-Aviles, G.; Miranda Mendez, G.I.; Santiago-Pagan, J.; Nieves-Santiago, M.; Alvarez-Carrillo, V.; Griebenow, K., Tinoco, A.D. “Cytochrome c: Using biological insight toward engineering an optimized anticáncer biodrug.” Inorganics 2021, 9, 83. https://doi.org/10.3390/inorganics9110083.
Gaur, K.; Perez Otero, S.C.; Benjamin-Rivera, J.A.; Rodriguez, I.; Loza-Rosas, S.A.; Vazquez-Salgado, A.M.; Akam, E.A.; Hernandez-Matias, L.; Sharma, R.K.; Alicea, N.; Kowaleff, M.; Washington, A.V.; Astashkin, A.V.; Tomat, E.; Tinoco, A.D.* “Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase.” J. Am. Chem. Soc. Au. 2021, doi:10.1021/jacsau.1c00078
Rodriguez, I.; Gautam, R.; Tinoco, A.D. “Using X-ray diffraction techniques for biomimetic drug development, formulation, and polymorphic characterization.” Biomimetics. 2021, doi: 10.3390/biomimetics6010001.
Delinois, L.J.; Peon, H.; Villalobos-Santos, J.C.; Ramirez-Paz, J.; Miller, J.; Griebenow, K.H.; Tinoco, A.D.* “A cytochrome c-chlorotoxin hybrid protein as a possible antiglioma drug.” ChemMedChem. 2020, 15(22), 2185-2192.
Benjamin-Rivera, J.A.; Cardona-Rivera, A.E.; Vazquez-Maldonado, A.L.; Dones-Lassalle, C.Y.; Pabon-Colon, H.L.; Rodriguez-Rivera, H.M.; Rodriguez, I.; Gonzalez-Espiet, J.C.; Catala-Torres, J.F.; Carrasquillo Rivera, M.; De Jesus-Soto, M.G.; Cordero-Virella, N.C.; Cruz-Maldonado, P.M.; Gonzalez-Pagan, P.; Hernandez-Rios, R.; Gaur, K.; Loza-Rosas, S.A.; Tinoco, A.D. “Exploring serum transferrin regulation of nonferric metal therapeutic function and toxicity.” Inorganics. 2020, 8(9), 48; doi: 10.3390/inorganics8090048.
Gaur, K.; Cruz, Y.M.; Santiago Espinoza, J.A.; Morales Rueda, C.A.; Loza-Rosas, S.A.; Fernandez-Vega, L.; Benjamin-Rivera, J.A.; Alvarez, A.; Tinoco, A.D.* “Exploring the pH dependent aqueous speciation of metal complexes through UV-Vis spectroscopy.” J. Chem. Ed. 2020, doi: 10.1021/acs.jchemed.9b01199.
Hanif, M.*; Yang, X., Tinoco, A.D.; and Plażuk, D. “Editorial: New Strategies in Design and Synthesis of Inorganic Pharmaceuticals.” Front. Chem. 2020, 8:453. doi: 10.3389/fchem.2020.00453.
Fernandez-Vega, L.; Ruiz Silva, V.A.; Domínguez-González, T.M.; Claudio-Betancourt, S.; Toro-Maldonado, R.E.; Capre Maso, L.C.; Sanabria Ortiz, K.; Pérez-Verdejo, J.A.; Román González, J.; Rosado-Fraticelli, G.T.; Pagán Meléndez, F.; Betancourt Santiago, F.M.; Rivera-Rivera, D.A.; Martínez Navarro, C.; Bruno Chardón, A.C. Vera, A.O.; Tinoco, A.D.* “Evaluating ligand modifications of the titanocene and auranofin moieties for the development of more potent anticancer drugs.” Inorganics. 2020, 8, doi: 10.3390/inorganics8020010.
Sharma, S.; Sharma, R.K.; Gaur, K.; Cátala Torres, J.F.; Loza-Rosas, S.A.; Torres, A.; Saxena, M. Julin, M. Tinoco, A.D.* “Fueling a hot debate on the application of TiO2 nanoparticles in sunscreen.” Materials. 2019, 12, doi: 10.3390/ ma12142317.
Saxena, M.; Loza-Rosas, S. A.; Gaur, K.; Sharma, S.; Otero, S. C. P.; Tinoco, A. D., Exploring titanium (IV) chemical proximity to iron (III) to elucidate a function for Ti (IV) in the human body. Coordination Chemistry Reviews 2018, 363, 109-125.
Saxena, M.; Delgado, Y.; Sharma, R. K.; Sharma, S.; Guzmán, S. L. P. D. L.; Tinoco, A. D.; Griebenow, K., Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. PloS one 2018, 13 (4), e0195542.
Carballeira, N. M.; Morales-Guzman, C.; Alvarez-Benedicto, E.; Torres-Martinez, Z.; Delgado, Y.; Griebenow, K. H.; Tinoco, A. D.; Reguera, R. M.; Perez-Pertejo, Y.; Carbajo-Andres, R., First total synthesis of ω-phenyl Δ6 fatty acids and their leishmanicidal and anticancer properties. Current topics in medicinal chemistry 2018, 18 (5), 418-427.
Das, S.; Parga, K.; Chakraborty, I.; Tinoco, A. D.; Delgado, Y.; López, P. M.; Fernández Vega, L.; Sanakis, Y.; Ghosh, S.; Bankson, J., Magnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents. Journal of inorganic biochemistry 2018, 186, 176-186.
Loza-Rosas, S.A.; Vazquez, A.M.; Rivero, K.I.; Negron, L.J.; Delgado, Y.; Benjamin-Rivera, J.A.; Vazquez-Maldonado, A.L.; Parks, T.B.; Munet-Colon, C.; Tinoco, A.D.* “Expanding the therapeutic potential of the iron chelator deferasirox in the development of aqueous stable Ti(IV) anticancer complexes.” Inorganic Chemistry. 2017, 56, 7788-7802.
Loza-Rosas, S.A.; Saxena, M.; Delgado, Y.; Gaur, K.; Pandrala, M.; Tinoco, A.D.* “Ubiquitous metal, Difficult to track: Towards an understanding of the bioactivity of Titanium(IV) in humans.” Metallomics, 2017, 9, 346-356.
Morales-Cruz, M.; Cruz-Montañez, A.; Figueroa, C.M.; González-Robles, T.; Davila, J.; Inyushin, M.; Loza-Rosas, S.A.; Molina, A.M.; Muñoz-Perez, L.; Kucheryavykh, L.Y.; Tinoco, A.D.; Griebenow, K. “Combining stimulus-triggered release and active targetting strategies improves cytotoxicity of cytochrome c nanoparticles in tumor cells.” Mol. Pharmaceutics, 2016, DOI: 10.1021/acs.molpharmaceut.6b00461.
Tinoco, A.D.*; Saxena, M.; Sharma, S.; Noinaj, N.; Delgado, Y.; Quiñones González, E.P.; Conklin, S.E.; Zambrana, N.; Loza-Rosas, S.A.; Parks, T.B. “Unusual synergism of transferrin and citrate in the regulation of Ti(IV) speciation, transport, and toxicity.” J. Amer. Chem. Soc., 2016, 138, 5659.
Saxena, M.; Kumar Sharma, R.; Ramirez-Paz, J.; Tinoco, A.D.; Griebenow, K.* "Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus" BMC Biochemistry 2015, 16:21
Parks, T.B.; Cruz, Y.M.; Tinoco, A.D.* “Applying the Fe(III) binding property of a chemical transferrin mimetic to Ti(IV) anticancer drug design.” Inorg Chem, 2014, 53, 1743.
Protein Database Structure: 5DYH Saxena, M.; Sharma, S.; Noinaj, N.; Parks, T.B.; Tinoco, A.D. “Ti(IV) bound human serum transferrin”
Mitchell, A.; Lone, A.M.; Tinoco, A.D.*; Saghatelian, A. “Proteolysis controls endogenous substance P levels.” PLOS ONE, 2013, 8(7): e68638. doi:10.13714/journal.pone.0068638.
Tinoco, A.D.*; Thomas, H.R.; Incarvito, C.D.; Saghatelian, A.; Valentine, A.M. “Cytotoxicity of a Ti(IV) complex is independent of serum proteins.” Proc. Natl. Acad. Sci., 2012, 109, 5016-5021
Delinois, L.J.; De Leon-Velez, O.; Vazquez-Medina, A.; Velez-Cabrera, A.; Marrero-Sanchez, A.; Nieves-Escobar, C.; Alfonso-Cano, D.; Caraballo-Rodriguez, D.; Rodriguez-Ortiz, J.; Acosta-Mercado, J.; Benjamin-Rivera, J.A.; Gonzalez-Gonzalez, K.; Fernandez-Adorno, K.; Santiago-Pagan, L.; Delgado-Vergara, R.; Torres-Avila, X.; Maser-Figueroa, A.; Grajales-Aviles, G.; Miranda Mendez, G.I.; Santiago-Pagan, J.; Nieves-Santiago, M.; Alvarez-Carrillo, V.; Griebenow, K., Tinoco, A.D. “Cytochrome c: Using biological insight toward engineering an optimized anticáncer biodrug.” Inorganics 2021, 9, 83. https://doi.org/10.3390/inorganics9110083.
Gaur, K.; Perez Otero, S.C.; Benjamin-Rivera, J.A.; Rodriguez, I.; Loza-Rosas, S.A.; Vazquez-Salgado, A.M.; Akam, E.A.; Hernandez-Matias, L.; Sharma, R.K.; Alicea, N.; Kowaleff, M.; Washington, A.V.; Astashkin, A.V.; Tomat, E.; Tinoco, A.D.* “Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase.” J. Am. Chem. Soc. Au. 2021, doi:10.1021/jacsau.1c00078
Rodriguez, I.; Gautam, R.; Tinoco, A.D. “Using X-ray diffraction techniques for biomimetic drug development, formulation, and polymorphic characterization.” Biomimetics. 2021, doi: 10.3390/biomimetics6010001.
Delinois, L.J.; Peon, H.; Villalobos-Santos, J.C.; Ramirez-Paz, J.; Miller, J.; Griebenow, K.H.; Tinoco, A.D.* “A cytochrome c-chlorotoxin hybrid protein as a possible antiglioma drug.” ChemMedChem. 2020, 15(22), 2185-2192.
Benjamin-Rivera, J.A.; Cardona-Rivera, A.E.; Vazquez-Maldonado, A.L.; Dones-Lassalle, C.Y.; Pabon-Colon, H.L.; Rodriguez-Rivera, H.M.; Rodriguez, I.; Gonzalez-Espiet, J.C.; Catala-Torres, J.F.; Carrasquillo Rivera, M.; De Jesus-Soto, M.G.; Cordero-Virella, N.C.; Cruz-Maldonado, P.M.; Gonzalez-Pagan, P.; Hernandez-Rios, R.; Gaur, K.; Loza-Rosas, S.A.; Tinoco, A.D. “Exploring serum transferrin regulation of nonferric metal therapeutic function and toxicity.” Inorganics. 2020, 8(9), 48; doi: 10.3390/inorganics8090048.
Gaur, K.; Cruz, Y.M.; Santiago Espinoza, J.A.; Morales Rueda, C.A.; Loza-Rosas, S.A.; Fernandez-Vega, L.; Benjamin-Rivera, J.A.; Alvarez, A.; Tinoco, A.D.* “Exploring the pH dependent aqueous speciation of metal complexes through UV-Vis spectroscopy.” J. Chem. Ed. 2020, doi: 10.1021/acs.jchemed.9b01199.
Hanif, M.*; Yang, X., Tinoco, A.D.; and Plażuk, D. “Editorial: New Strategies in Design and Synthesis of Inorganic Pharmaceuticals.” Front. Chem. 2020, 8:453. doi: 10.3389/fchem.2020.00453.
Fernandez-Vega, L.; Ruiz Silva, V.A.; Domínguez-González, T.M.; Claudio-Betancourt, S.; Toro-Maldonado, R.E.; Capre Maso, L.C.; Sanabria Ortiz, K.; Pérez-Verdejo, J.A.; Román González, J.; Rosado-Fraticelli, G.T.; Pagán Meléndez, F.; Betancourt Santiago, F.M.; Rivera-Rivera, D.A.; Martínez Navarro, C.; Bruno Chardón, A.C. Vera, A.O.; Tinoco, A.D.* “Evaluating ligand modifications of the titanocene and auranofin moieties for the development of more potent anticancer drugs.” Inorganics. 2020, 8, doi: 10.3390/inorganics8020010.
Sharma, S.; Sharma, R.K.; Gaur, K.; Cátala Torres, J.F.; Loza-Rosas, S.A.; Torres, A.; Saxena, M. Julin, M. Tinoco, A.D.* “Fueling a hot debate on the application of TiO2 nanoparticles in sunscreen.” Materials. 2019, 12, doi: 10.3390/ ma12142317.
Saxena, M.; Loza-Rosas, S. A.; Gaur, K.; Sharma, S.; Otero, S. C. P.; Tinoco, A. D., Exploring titanium (IV) chemical proximity to iron (III) to elucidate a function for Ti (IV) in the human body. Coordination Chemistry Reviews 2018, 363, 109-125.
Saxena, M.; Delgado, Y.; Sharma, R. K.; Sharma, S.; Guzmán, S. L. P. D. L.; Tinoco, A. D.; Griebenow, K., Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. PloS one 2018, 13 (4), e0195542.
Carballeira, N. M.; Morales-Guzman, C.; Alvarez-Benedicto, E.; Torres-Martinez, Z.; Delgado, Y.; Griebenow, K. H.; Tinoco, A. D.; Reguera, R. M.; Perez-Pertejo, Y.; Carbajo-Andres, R., First total synthesis of ω-phenyl Δ6 fatty acids and their leishmanicidal and anticancer properties. Current topics in medicinal chemistry 2018, 18 (5), 418-427.
Das, S.; Parga, K.; Chakraborty, I.; Tinoco, A. D.; Delgado, Y.; López, P. M.; Fernández Vega, L.; Sanakis, Y.; Ghosh, S.; Bankson, J., Magnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents. Journal of inorganic biochemistry 2018, 186, 176-186.
Loza-Rosas, S.A.; Vazquez, A.M.; Rivero, K.I.; Negron, L.J.; Delgado, Y.; Benjamin-Rivera, J.A.; Vazquez-Maldonado, A.L.; Parks, T.B.; Munet-Colon, C.; Tinoco, A.D.* “Expanding the therapeutic potential of the iron chelator deferasirox in the development of aqueous stable Ti(IV) anticancer complexes.” Inorganic Chemistry. 2017, 56, 7788-7802.
Loza-Rosas, S.A.; Saxena, M.; Delgado, Y.; Gaur, K.; Pandrala, M.; Tinoco, A.D.* “Ubiquitous metal, Difficult to track: Towards an understanding of the bioactivity of Titanium(IV) in humans.” Metallomics, 2017, 9, 346-356.
Morales-Cruz, M.; Cruz-Montañez, A.; Figueroa, C.M.; González-Robles, T.; Davila, J.; Inyushin, M.; Loza-Rosas, S.A.; Molina, A.M.; Muñoz-Perez, L.; Kucheryavykh, L.Y.; Tinoco, A.D.; Griebenow, K. “Combining stimulus-triggered release and active targetting strategies improves cytotoxicity of cytochrome c nanoparticles in tumor cells.” Mol. Pharmaceutics, 2016, DOI: 10.1021/acs.molpharmaceut.6b00461.
Tinoco, A.D.*; Saxena, M.; Sharma, S.; Noinaj, N.; Delgado, Y.; Quiñones González, E.P.; Conklin, S.E.; Zambrana, N.; Loza-Rosas, S.A.; Parks, T.B. “Unusual synergism of transferrin and citrate in the regulation of Ti(IV) speciation, transport, and toxicity.” J. Amer. Chem. Soc., 2016, 138, 5659.
Saxena, M.; Kumar Sharma, R.; Ramirez-Paz, J.; Tinoco, A.D.; Griebenow, K.* "Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus" BMC Biochemistry 2015, 16:21
Parks, T.B.; Cruz, Y.M.; Tinoco, A.D.* “Applying the Fe(III) binding property of a chemical transferrin mimetic to Ti(IV) anticancer drug design.” Inorg Chem, 2014, 53, 1743.
Protein Database Structure: 5DYH Saxena, M.; Sharma, S.; Noinaj, N.; Parks, T.B.; Tinoco, A.D. “Ti(IV) bound human serum transferrin”
Mitchell, A.; Lone, A.M.; Tinoco, A.D.*; Saghatelian, A. “Proteolysis controls endogenous substance P levels.” PLOS ONE, 2013, 8(7): e68638. doi:10.13714/journal.pone.0068638.
Tinoco, A.D.*; Thomas, H.R.; Incarvito, C.D.; Saghatelian, A.; Valentine, A.M. “Cytotoxicity of a Ti(IV) complex is independent of serum proteins.” Proc. Natl. Acad. Sci., 2012, 109, 5016-5021
Previous Publications
Tinoco, A.D. and Saghatelian, A. “Investigating endogenous peptides and peptidases using peptidomics.” Biochemistry, 2011, 50, 7447-7461.
Tinoco, A.D.; Kim, YG., Tagore, D.M.; Wiwczar, J.; Danial, N.N.; Saghatelian, A. “A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones.” Biochemistry, 2011, 50, 2213-2222.
Tinoco, A.D.; Tagore, D.M.; Saghatelian, A. “Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform.” J. Am. Chem. Soc., 2010, 132, 3819-3830.
Lone, A.M.; Nolte, W.M.; Tinoco, A.D.; Saghatelian, A. “Peptidomics of the prolyl peptidases.” AAPS J. 2010.
Siburt, C.J.P.; Lin, E.M.; Brandt, S.J. Tinoco, A.D.; Valentine, A.M.; Crumbliss, A.L. “Redox potentials of Ti(IV) and Fe(III) complexes provide insights into titanium biodistribution mechanisms.” J. Inorg. Biochem., 2010, 104, 1006-1009.
Tinoco, A.D.; Peterson, C.W.; Lucchese, B.; Doyle, R.P.; Valentine, A.M. “On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis.” Proc. Nat. Acad. Sci. 2008, 105, 3268-3273.
Tinoco, A.D.; Eames, E.V.; Valentine, A.M.* “Reconsideration of serum Ti(IV) transport: Albumin and transferrin trafficking of Ti(IV) and its complexes.” J. Am. Chem. Soc., 2008, 130, 2262.
Tinoco, A.D.*; Eames, E.V.; Incarvito, C.D.; Valentine, A.M. “Hydrolytic metal with a hydrophobic periphery: Titanium(IV) complexes of naphthalene-2,3-diolate, and interactions with serum albumin.” Inorg. Chem., 2008, 47, 8380-8390.
Tinoco, A.D.; Incarvito, C.D.; Valentine, A.M.* “Calorimetric, spectroscopic, and model studies provide insight into the transport of Ti(IV) by human serum transferrin.” J. Am. Chem. Soc., 2007, 129, 3444.
Tinoco, A.D.; Valentine, A.M.* “Ti(IV) Binds to human serum transferrin more tightly than does Fe(III).” J. Am. Chem. Soc., 2005, 127, 11218.
Howard, D.L.; Tinoco, A.D.; Brudvig, G.W.; Vrettos, J.S.; Allen, B.C.* “Catalytic oxygen evolution by a bioinorganic model of the photosystem II oxygen-evolving complex.” J. Chem. Educ., 2005, 82, 791.
* Denotes corresponding author.
Oral and Poster Presentations
Nieves Escobar, Christopher. “Synthesis of a deferasirox-triapine conjugate as a bifunctional iron chelating ligand for the development of novel Ti(IV) complexes with enhanced anticancer potency.” Poster given at the American Chemical Society Spring 2021 (Virtual), April 2021.
Maser-Figueroa, Andrea N. “Impacting human health by transmetalation between copper (II) and the anti-cancer compound titanium(IV) deferasirox” Poster given at the American Chemical Society Spring 2021 (Virtual), April 2021.
Rodriguez, Israel. “Elucidating ribonucleotide reductase inhibition by compounds of titanium(IV) chemical transferrin mimics as an Anticancer Drug Strategy.” 8th BioXFEL International Virtual Conference, February 2021.
De Leon Velez, Omar O. “Vanadium(IV) chemical transferrin mimetics as anti-type 2 diabetic agents.” Lecture given at the 12th Annual Gulf Coast Undergraduate Research Symposium (GCURS) at Rice University (Virtual), October 2020.
Rodriguez, Israel. “Elucidating ribonucleotide reductase inhibition by compounds of titanium(IV) chemical transferrin mimics as an Anticancer Drug Strategy.” Oral lecture given at American Chemical Society Fall 2020 (Virtual), August 2020.
Torres, A. “Exploring the role of iron(III)-bound serum transferrin in regulating the stability and transport of titanium(IV). Oral lecture given at American Chemical Society Fall 2020 (Virtual), August 2020.
Transmetalation with a titanium(IV) compound transforms biofunctional copper into a cytotoxic agent. Oral presentation. Loza-Rosas, S.A.; Tinoco, A.D. 7th Latin American Symposium on Coordination and Organometallic Chemistry, Cartagena, Colombia. 27-30 August 2019.
Using fluorescent confocal microscopy to study the endocytosis delivery of Ti(IV) by serum Transferrin. Poster presentation. Benjamin-Rivera, J.A.; Vazquez, A.L.; Rodriguez, J.D.; Tinoco, A.D. 7th Latin American Symposium on Coordination and Organometallic Chemistry, Cartagena, Colombia. 27-30 August 2019. Received a Best Poster Award.
Recombinant human cytochrome c tagged-chlorotoxin as a targeting model drug for treatment of gliomas. Oral and poster presentation. Peon Castro, H.; Delinois, L.J.; Tinoco, A.D. 2019 Annual NIDDK STEP-UP High School Scientific Session and Summer Research Presentations, NIH Bethesda, MD. August 4th-8th, 2019. Sponsored by the NIH STEP UP program.
Cellular uptake determination of titanium(IV) via serum transferrin (sTf) using fluorescence confocal microscopy. Poster presentation. Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Torres, A.; Tinoco, A.D. 2019 Jack Kent Cooke Foundation Scholarship, Lansdowne, VA. August 2019.
Exploring the role of iron(III)-bound serum transferrin in regulating the stability and transport of titanium(IV). Poster presentation. Torres, A.; Benjamin-Rivera, J.A.; Tinoco, A.D. 4th NSF REU PR CLIMB Closing Ceremony Symposium, University of Puerto Rico Rio Piedras, PR, July 25, 2019. Awarded 1st Place.
Cellular uptake determination of titanium(IV) via serum transferrin (sTf) using fluorescence confocal microscopy. Oral presentation. Rodriguez Rivera, J.D; Benjamin-Rivera, J.A.; Torres, A.; Tinoco, A.D. 2019 ACS Project SEED Symposium, University of Puerto Rico Rio Piedras. July 19, 2019.
The Study of Titanium(IV) Metal Complexes containing Iron Chelating Ligands for Cancer Therapy. Oral presentation. Rodriguez, N.; Rodriguez, I.; Tinoco, A.D. 2019 ACS Project SEED Symposium, July 19, 2019.
Understanding the knowledge of the mechanism of action and improvement of the selectivity of the titanium (IV) deferasirox complex. Poster presentation. Fernandez, L.V.; Tinoco, A.D.; 15th International Symposium on Applied Bioinorganic Chemistry, Nara, Japan, June 2nd-5th, 2019.
Determining the Potential Role that Fe (III) Plays in Human Serum Transferrin Transport of Non-Iron Metals by Focusing on Titanium(IV). Oral presentation. Catala Torres, J.F.; Tinoco, A.D. 53rd ACS Junior technical meeting/38th Puerto Rico interdisciplinary scientific conference, University of Puerto Rico Mayaguez, PR, May 2, 2019.
Tinoco, A.D. 53rd ACS Junior technical meeting/38th Puerto Rico interdisciplinary scientific conference, University of Puerto Rico Mayaguez, PR, May 2, 2019.
Determination of titanium(IV) transportation in the body through serum blood transferrin (sTf). Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Tinoco, A.D. Poster presentation. 2019 Puerto Rico Metropolitan Science Fair, San Juan, PR. March 2019. Awarded 1st Place.
Cytotoxic evaluation of a peptide-conjugated anticancer titanium (IV)-based complex. Oral presentation. Rodriguez, I.M.; Fernandez, L.V.; Tinoco, A.D. 2019 Puerto Rico Metropolitan Science Fair, San Juan, PR. March 2019.
Determination of titanium(IV) transportation in the body through serum blood transferrin (sTf). Poster presentation. Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Tinoco, A.D. 3rd Interdisciplinary Research Symposium, San Juan Baptista School of Medicine, Caguas, PR. February 28, 2019.
Exploring the anticancer potential of titanium(IV) salicylate as an inhibitor of intracellular iron. Poster presentation. Gonzalez-Pagan, P.; Gaur, K.; Saxena, M.; and Tinoco, A.D. BioXFEL, 6th international conference, San Diego, Feb 12th-14th, 2019. Received a BioXFEL Travel Award.
Studies of Ti(IV) in living cells to understand a possible endocytosis route using fluorescent molecules. Poster presentation. Benjamin-Rivera, J.A.; Vázquez-Maldonado, A.L.; Rodriguez, J.D.; Tinoco, A.D. BioXFEL, 6th international conference, San Diego, Feb 12th-14th, 2019. Received a BioXFEL Travel Award.
Participated in the 13th LFD Workshop in Advanced Fluorescence Imaging and Dynamics. Also offered a Poster presentation on “Fluorescent Studies to Understand Cellular Uptake of Ti(IV) Via Human Serum Transferrin(hTf).” University of California, Irvine, CA, Oct 22nd-26th, 2018.
Study of the Mechanism of Action of Titanium (IV) Complexes for an Anticancer Drug Design Strategy. Poster presentation. Pérez-Otero, S.C.; Gaur, K.; Akam, E.; Delgado, Y.; Tomat, E.; Tinoco, A.D. Emory University STEM Research and Career Symposium, Emory Conference Center Hotel, Sept. 30th- Oct. 2nd, 2018. Received a PR INBRE Travel Award.
Exploring Vanadium Chemical Transferrin Mimetic Compounds for Insulin Enhancement. Oral and poster presentation. Feliciano, A.M.; Loza-Rosas, S.A.; Tinoco, A.D. 2018 Annual NIDDK STEP-UP High School Scientific Session and Summer Research Presentations, NIH, Bethesda, MD. August 5th-9th, 2018. Sponsored by the NIH STEP UP program.
Exploring protein regulation of titanium(IV) transport and activity. Poster presentation. DaCunha, J.; Saxena, M.; Tinoco, A.D. 3rd NSF REU PR CLIMB Closing Ceremony Symposium, University of Puerto Rico Rio Piedras, PR, July 26, 2018.
Cytotoxic evaluation of a peptide-conjugated anticancer titanium (IV)-based complex. Oral presentation. Rodriguez, I.M.; Fernandez, L.V.; Tinoco, A.D. 2018 ACS Project SEED Symposium, University of Puerto Rico Rio Piedras. July 20, 2018.
Determination of titanium(IV) transportation in the body through serum blood transferrin (sTf). Oral presentation. Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Tinoco, A.D. 2018 ACS Project SEED Symposium, University of Puerto Rico Rio Piedras. July 20, 2018.
Anti-cancer titanium complexes of iron chelator ligands: Exploring the mode of action. Poster presentation. Gaur, K.; Perez, S.C.; Akam, E.; Tomat, E.; Vázquez, A.M.; Tinoco. A.D. Gordon Research Conference: Metals in medicine, Proctor Academy, Andover, NH, June 24th-29th, 2018.
Development of peptide-conjugate ligands for selective delivery of anticancer Titanium(IV) compounds. Poster Presentation. Fernandez, L.V.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Titanium complexes with iron chelating ligands: Exploring the mode of action against cancer. Poster Presentation. Gaur, K.; Pérez, S.C.; Vázquez, A.M.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Transmetalation with a titanium(IV) compound transforms biofunctional copper into a cytotoxic agent. Poster Presentation. Loza-Rosas, S.A.; Morales-Rodriguez, S.; Zayas-Ortiz, A.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Determining the Ti(IV) sTf speciation responsible for optimal uptake of Ti(IV) into cells. Oral Presentation. Zambrana, N.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Saxena, M. Participated in the RapiData 2018 Workshop. SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA, April 22nd-27th, 2018.
Saxena, M. Participated in the BioSAXS Essentials 8: Getting started in biological small-angle X-ray solution scattering. CHESS Wilson Laboratory, Cornell University, Ithaca, NY, April 13th-15th, 2018.
Ti(Deferasirox)2, a highly cytotoxic chemical transferrin mimetic Ti(IV)-based compound, displays one of the highest aqueous stabilities in the Ti(IV)-based anticancer field. Poster presentation. Vázquez-Maldonado, A.L.; Benjamin-Rivera, J.A.; Tinoco, A.D. 255th ACS National Meeting, New Orleans, LA, March 18th-21st, 2018.
Identifying iron(III)-bound serum transferrin regulation of titanium(IV) blood speciation and transport within the human body. Benjamin-Rivera, J.A.; Delgado, Y.; Pandrala, M.; Vázquez-Maldonado, A.L.; Vazquez-Salgado, A.M. Tinoco, A.D. 255th ACS National Meeting, New Orleans, LA, March 18th-21st, 2018.
Inducing cell death in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. Poster presentation. Saxena, M.; Delgado, Y.; Sharma, R.; Sharma, S.; Guzman, S.; Tinoco, A.D.; Griebenow, K.H. BioXFEL, 5th international conference, New Orleans, LA, Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Construction and characterization of a cytochrome c-Ti transferrin conjugate for inducing cancer cell death. Poster presentation. Rodriguez-Acevedo, X.C.; Saxena, M.; Tinoco, A.D. BioXFEL, 5th international conference, New Orleans, LA. Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Elucidating the mechanism of action of titanium(IV) complexes for a new anticancer drug design strategy. Poster presentation. Pérez, S.C.; Gaur, K.; Akam, E.; Delgado, Y.; Tomat, E.; Tinoco, A.D. BioXFEL, 5th international conference, New Orleans, LA Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Fluorescent studies to track Ti(IV) serum transferrin transport into human cells. Poster presentation. Benjamin-Rivera, J.A.; Delgado, Y.; Pandrala, M.; Vázquez-Maldonado, A.L.; Vazquez-Salgado, A.M. Tinoco, A.D. BioXFEL, 5th international conference, New Orleans, LA. Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Development of peptide-conjugate ligands for selective delivery of anticancer Titanium(IV) compounds. Poster presentation. Fernandez Vega, L.V.; Tinoco, A.D.; Pandrala, M.; Serrano, F. 14th International Symposium on Applied Bioinorganic Chemistry, Toulouse, France. 7-10 June 2017.
Total Synthesis, Antileishmanial and Anticancer Activity of the Acetylenic Fatty Acids 6-Hexadecynoic, 16-Phenyl-6-hexadecynoic, and 10-Cyclohexyl-6-decynoic Acids. Poster presentation. Álvarez, E.; Carballeira, N.M.; Morales, C.; Delgado, Y.; Tinoco, A.D.; Reguera, R.M.; Álvarez-Velilla, R.; Balaña Fouce, R. American Society for Biochemistry and Molecular Biology (ASBMB) 2017 Annual Meeting, Chicago, IL. 22-26 April 2017.
Elucidation of the cell death pathways induced by aqueous-stable Titanium(IV) compounds as potential anticancer agents. Oral and Poster presentations. Delgado Y.; Vázquez A.M.; Kowaleff M.; Saxena M.; Torres, Z.; and Tinoco A.D. Experimental Biology Conference, Chicago, IL. April 2017.
Targeted cytochrome c delivery to cancer cells using the transferrin receptor. Poster presentation. Saxena, M.; Delgado, Y.; Sharma, R.K.; Sharma, S.; Guzmán, S.P.; Tinoco, A.D.; Griebenow, K.H. 253rd American Chemical Society, National Meeting & Exposition, San Francisco, CA. 2-6 April 2017.
Ribonucleotide reductase enzyme a target for Titanium complexes: A strategy to cure cancer. Poster presentation. Gaur, K.; Pérez, S.M.; Akam, E.; Tomat, E.; Saxena, M.; Sharma, R.K.; Tinoco, A.D., 253rd American Chemical Society, National Meeting & Exposition, San Francisco, CA. 2-6 April 2017.
The role of citrate and transferrin in determining Ti(IV) solubility, bioavailability, and its regulation. Poster presentation. Sharma, S.; Saxena, M.; Tinoco, A.D., 253rd American Chemical Society, National Meeting & Exposition, San Francisco, CA. 2-6 April 2017.
Intracellular tracing of deferasirox and its Ti(IV) complex by the FITC probe to study their cytotoxic mechanism of action. Oral presentation. Kowaleff, M.; Delgado, Y.; Tinoco, A.D. 253rd American Chemical Society National Meeting & Exposition, Oral presentation, San Francisco, CA. 2-6 April 2017.
Synthesis and Biological Evaluation of α-Methoxylated Acetylenic Fatty Acids. Oral presentation. Morales, C.; Álvarez, E.; Torres, Z.; Delgado, Y.; Tinoco, A. D.; Balaña Fouce, R.; Carballeira, N. M. 253rd American Chemical Society National Meeting & Exposition, Oral presentation, San Francisco, CA. 2-6 April 2017.
Elucidating titanium(IV) inhibition of cellular iron(III) dependence as an anticancer drug design strategy. Poster presentation. Pérez Otero, S.; Tinoco, A.D. INBRE External Advisory Committee Meeting, Dorado, PR. March 2017.
Ti(IV) Bound Transferrin X-ray Crystal Structure Reveals Citrate’s Synergistic Role in Ti-Transferrin Binding. Poster presentation. Saxena, M.; Sharma, S.; Noinaj, N.; and Tinoco, A.D. 4th Annual BioXFEL conference at Hotel Caesars Palace, Las Vegas, NV, USA. 10-12 January, 2017.
Targeted cytochrome c delivery to cancer cells using the transferrin receptor. Poster presentation. Saxena, M.; Delgado, Y.; Sharma, R.K.; Sharma, S.; Guzmán, S.P.; Tinoco, A.D.; Griebenow, K.H. Cell Biology 2016 ASCB Annual Meeting, San Francisco, CA. December 2016.
Determination of Ti(IV) metallome in the cellular environment and its utility in the designing of the anticancer drugs. Poster presentation. Gaur, K.; Tinoco, A.D. Casa Abierta Programas Graduados, Faculty of Natural Sciences, Universidad de Puerto Rico, Río Piedras, PR. 21 October 2016.
Expanding the therapeutic potential of deferasirox in Ti(IV) anticancer drug design. Poster presentation. Loza-Rosas, S.A. V Latin American Meeting on Biological Inorganic Chemistry. Querétaro, México. October 2016.
Elucidating titanium(IV) inhibition of cellular iron(III) dependence as an anticancer drug design strategy. Oral presentation. Pérez Otero, S.; Tinoco, A.D. Gulf Coast Undergraduate Research Symposium, Rice University, Houston, Texas. October 2016.
Cell death pathways induced by Titanium(IV) Deferasirox as potential anticancer complex. Delgado Y.; Vázquez A.M.; Kowaleff, M.; Saxena, M.; Torres, Z.; and Tinoco, A.D. Poster presentation. Forward Research & Innovation Summit, San Juan, PR. September 2016.
Exploring the strategies to find effective delivery vehicles for Ti(IV) compounds. Pandrala, M.; Parham, L.R.; Casañas-Montes, B.; and Tinoco, A.D. Poster presentation. Forward Research & Innovation Summit, San Juan, PR. September 2016.
Synergism of citrate and transferrin revealing Ti-Tf binding, transport and regulation. Quiñones González, E.P.; Tinoco, A.D. Poster presentation. 51ST ACS PR CHEM 2016, San Juan, PR. August 2016.
Undergraduate research as a fundamental mechanism towards a higher education: Research Experience for Undergraduates PR-CLIMB. Poster presentation. Cruz-Galarza, Y.M.; Fuentes-Vergara, C.; Tinoco, A.D. 2016 Biennial Conference on Chemical Education, Poster presentation, University of Northern Colorado. July 2016.
Maser-Figueroa, Andrea N. “Impacting human health by transmetalation between copper (II) and the anti-cancer compound titanium(IV) deferasirox” Poster given at the American Chemical Society Spring 2021 (Virtual), April 2021.
Rodriguez, Israel. “Elucidating ribonucleotide reductase inhibition by compounds of titanium(IV) chemical transferrin mimics as an Anticancer Drug Strategy.” 8th BioXFEL International Virtual Conference, February 2021.
De Leon Velez, Omar O. “Vanadium(IV) chemical transferrin mimetics as anti-type 2 diabetic agents.” Lecture given at the 12th Annual Gulf Coast Undergraduate Research Symposium (GCURS) at Rice University (Virtual), October 2020.
Rodriguez, Israel. “Elucidating ribonucleotide reductase inhibition by compounds of titanium(IV) chemical transferrin mimics as an Anticancer Drug Strategy.” Oral lecture given at American Chemical Society Fall 2020 (Virtual), August 2020.
Torres, A. “Exploring the role of iron(III)-bound serum transferrin in regulating the stability and transport of titanium(IV). Oral lecture given at American Chemical Society Fall 2020 (Virtual), August 2020.
Transmetalation with a titanium(IV) compound transforms biofunctional copper into a cytotoxic agent. Oral presentation. Loza-Rosas, S.A.; Tinoco, A.D. 7th Latin American Symposium on Coordination and Organometallic Chemistry, Cartagena, Colombia. 27-30 August 2019.
Using fluorescent confocal microscopy to study the endocytosis delivery of Ti(IV) by serum Transferrin. Poster presentation. Benjamin-Rivera, J.A.; Vazquez, A.L.; Rodriguez, J.D.; Tinoco, A.D. 7th Latin American Symposium on Coordination and Organometallic Chemistry, Cartagena, Colombia. 27-30 August 2019. Received a Best Poster Award.
Recombinant human cytochrome c tagged-chlorotoxin as a targeting model drug for treatment of gliomas. Oral and poster presentation. Peon Castro, H.; Delinois, L.J.; Tinoco, A.D. 2019 Annual NIDDK STEP-UP High School Scientific Session and Summer Research Presentations, NIH Bethesda, MD. August 4th-8th, 2019. Sponsored by the NIH STEP UP program.
Cellular uptake determination of titanium(IV) via serum transferrin (sTf) using fluorescence confocal microscopy. Poster presentation. Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Torres, A.; Tinoco, A.D. 2019 Jack Kent Cooke Foundation Scholarship, Lansdowne, VA. August 2019.
Exploring the role of iron(III)-bound serum transferrin in regulating the stability and transport of titanium(IV). Poster presentation. Torres, A.; Benjamin-Rivera, J.A.; Tinoco, A.D. 4th NSF REU PR CLIMB Closing Ceremony Symposium, University of Puerto Rico Rio Piedras, PR, July 25, 2019. Awarded 1st Place.
Cellular uptake determination of titanium(IV) via serum transferrin (sTf) using fluorescence confocal microscopy. Oral presentation. Rodriguez Rivera, J.D; Benjamin-Rivera, J.A.; Torres, A.; Tinoco, A.D. 2019 ACS Project SEED Symposium, University of Puerto Rico Rio Piedras. July 19, 2019.
The Study of Titanium(IV) Metal Complexes containing Iron Chelating Ligands for Cancer Therapy. Oral presentation. Rodriguez, N.; Rodriguez, I.; Tinoco, A.D. 2019 ACS Project SEED Symposium, July 19, 2019.
Understanding the knowledge of the mechanism of action and improvement of the selectivity of the titanium (IV) deferasirox complex. Poster presentation. Fernandez, L.V.; Tinoco, A.D.; 15th International Symposium on Applied Bioinorganic Chemistry, Nara, Japan, June 2nd-5th, 2019.
Determining the Potential Role that Fe (III) Plays in Human Serum Transferrin Transport of Non-Iron Metals by Focusing on Titanium(IV). Oral presentation. Catala Torres, J.F.; Tinoco, A.D. 53rd ACS Junior technical meeting/38th Puerto Rico interdisciplinary scientific conference, University of Puerto Rico Mayaguez, PR, May 2, 2019.
Tinoco, A.D. 53rd ACS Junior technical meeting/38th Puerto Rico interdisciplinary scientific conference, University of Puerto Rico Mayaguez, PR, May 2, 2019.
Determination of titanium(IV) transportation in the body through serum blood transferrin (sTf). Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Tinoco, A.D. Poster presentation. 2019 Puerto Rico Metropolitan Science Fair, San Juan, PR. March 2019. Awarded 1st Place.
Cytotoxic evaluation of a peptide-conjugated anticancer titanium (IV)-based complex. Oral presentation. Rodriguez, I.M.; Fernandez, L.V.; Tinoco, A.D. 2019 Puerto Rico Metropolitan Science Fair, San Juan, PR. March 2019.
Determination of titanium(IV) transportation in the body through serum blood transferrin (sTf). Poster presentation. Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Tinoco, A.D. 3rd Interdisciplinary Research Symposium, San Juan Baptista School of Medicine, Caguas, PR. February 28, 2019.
Exploring the anticancer potential of titanium(IV) salicylate as an inhibitor of intracellular iron. Poster presentation. Gonzalez-Pagan, P.; Gaur, K.; Saxena, M.; and Tinoco, A.D. BioXFEL, 6th international conference, San Diego, Feb 12th-14th, 2019. Received a BioXFEL Travel Award.
Studies of Ti(IV) in living cells to understand a possible endocytosis route using fluorescent molecules. Poster presentation. Benjamin-Rivera, J.A.; Vázquez-Maldonado, A.L.; Rodriguez, J.D.; Tinoco, A.D. BioXFEL, 6th international conference, San Diego, Feb 12th-14th, 2019. Received a BioXFEL Travel Award.
Participated in the 13th LFD Workshop in Advanced Fluorescence Imaging and Dynamics. Also offered a Poster presentation on “Fluorescent Studies to Understand Cellular Uptake of Ti(IV) Via Human Serum Transferrin(hTf).” University of California, Irvine, CA, Oct 22nd-26th, 2018.
Study of the Mechanism of Action of Titanium (IV) Complexes for an Anticancer Drug Design Strategy. Poster presentation. Pérez-Otero, S.C.; Gaur, K.; Akam, E.; Delgado, Y.; Tomat, E.; Tinoco, A.D. Emory University STEM Research and Career Symposium, Emory Conference Center Hotel, Sept. 30th- Oct. 2nd, 2018. Received a PR INBRE Travel Award.
Exploring Vanadium Chemical Transferrin Mimetic Compounds for Insulin Enhancement. Oral and poster presentation. Feliciano, A.M.; Loza-Rosas, S.A.; Tinoco, A.D. 2018 Annual NIDDK STEP-UP High School Scientific Session and Summer Research Presentations, NIH, Bethesda, MD. August 5th-9th, 2018. Sponsored by the NIH STEP UP program.
Exploring protein regulation of titanium(IV) transport and activity. Poster presentation. DaCunha, J.; Saxena, M.; Tinoco, A.D. 3rd NSF REU PR CLIMB Closing Ceremony Symposium, University of Puerto Rico Rio Piedras, PR, July 26, 2018.
Cytotoxic evaluation of a peptide-conjugated anticancer titanium (IV)-based complex. Oral presentation. Rodriguez, I.M.; Fernandez, L.V.; Tinoco, A.D. 2018 ACS Project SEED Symposium, University of Puerto Rico Rio Piedras. July 20, 2018.
Determination of titanium(IV) transportation in the body through serum blood transferrin (sTf). Oral presentation. Rodriguez Rivera, J.D.; Benjamin-Rivera, J.A.; Tinoco, A.D. 2018 ACS Project SEED Symposium, University of Puerto Rico Rio Piedras. July 20, 2018.
Anti-cancer titanium complexes of iron chelator ligands: Exploring the mode of action. Poster presentation. Gaur, K.; Perez, S.C.; Akam, E.; Tomat, E.; Vázquez, A.M.; Tinoco. A.D. Gordon Research Conference: Metals in medicine, Proctor Academy, Andover, NH, June 24th-29th, 2018.
Development of peptide-conjugate ligands for selective delivery of anticancer Titanium(IV) compounds. Poster Presentation. Fernandez, L.V.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Titanium complexes with iron chelating ligands: Exploring the mode of action against cancer. Poster Presentation. Gaur, K.; Pérez, S.C.; Vázquez, A.M.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Transmetalation with a titanium(IV) compound transforms biofunctional copper into a cytotoxic agent. Poster Presentation. Loza-Rosas, S.A.; Morales-Rodriguez, S.; Zayas-Ortiz, A.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Determining the Ti(IV) sTf speciation responsible for optimal uptake of Ti(IV) into cells. Oral Presentation. Zambrana, N.; Tinoco, A.D. 52nd ACS Junior technical meeting/37th Puerto Rico interdisciplinary scientific conference, Universidad del Turabo, PR, April 28, 2018.
Saxena, M. Participated in the RapiData 2018 Workshop. SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA, April 22nd-27th, 2018.
Saxena, M. Participated in the BioSAXS Essentials 8: Getting started in biological small-angle X-ray solution scattering. CHESS Wilson Laboratory, Cornell University, Ithaca, NY, April 13th-15th, 2018.
Ti(Deferasirox)2, a highly cytotoxic chemical transferrin mimetic Ti(IV)-based compound, displays one of the highest aqueous stabilities in the Ti(IV)-based anticancer field. Poster presentation. Vázquez-Maldonado, A.L.; Benjamin-Rivera, J.A.; Tinoco, A.D. 255th ACS National Meeting, New Orleans, LA, March 18th-21st, 2018.
Identifying iron(III)-bound serum transferrin regulation of titanium(IV) blood speciation and transport within the human body. Benjamin-Rivera, J.A.; Delgado, Y.; Pandrala, M.; Vázquez-Maldonado, A.L.; Vazquez-Salgado, A.M. Tinoco, A.D. 255th ACS National Meeting, New Orleans, LA, March 18th-21st, 2018.
Inducing cell death in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. Poster presentation. Saxena, M.; Delgado, Y.; Sharma, R.; Sharma, S.; Guzman, S.; Tinoco, A.D.; Griebenow, K.H. BioXFEL, 5th international conference, New Orleans, LA, Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Construction and characterization of a cytochrome c-Ti transferrin conjugate for inducing cancer cell death. Poster presentation. Rodriguez-Acevedo, X.C.; Saxena, M.; Tinoco, A.D. BioXFEL, 5th international conference, New Orleans, LA. Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Elucidating the mechanism of action of titanium(IV) complexes for a new anticancer drug design strategy. Poster presentation. Pérez, S.C.; Gaur, K.; Akam, E.; Delgado, Y.; Tomat, E.; Tinoco, A.D. BioXFEL, 5th international conference, New Orleans, LA Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Fluorescent studies to track Ti(IV) serum transferrin transport into human cells. Poster presentation. Benjamin-Rivera, J.A.; Delgado, Y.; Pandrala, M.; Vázquez-Maldonado, A.L.; Vazquez-Salgado, A.M. Tinoco, A.D. BioXFEL, 5th international conference, New Orleans, LA. Feb 13th-15th, 2018. Received a BioXFEL Travel Award.
Development of peptide-conjugate ligands for selective delivery of anticancer Titanium(IV) compounds. Poster presentation. Fernandez Vega, L.V.; Tinoco, A.D.; Pandrala, M.; Serrano, F. 14th International Symposium on Applied Bioinorganic Chemistry, Toulouse, France. 7-10 June 2017.
Total Synthesis, Antileishmanial and Anticancer Activity of the Acetylenic Fatty Acids 6-Hexadecynoic, 16-Phenyl-6-hexadecynoic, and 10-Cyclohexyl-6-decynoic Acids. Poster presentation. Álvarez, E.; Carballeira, N.M.; Morales, C.; Delgado, Y.; Tinoco, A.D.; Reguera, R.M.; Álvarez-Velilla, R.; Balaña Fouce, R. American Society for Biochemistry and Molecular Biology (ASBMB) 2017 Annual Meeting, Chicago, IL. 22-26 April 2017.
Elucidation of the cell death pathways induced by aqueous-stable Titanium(IV) compounds as potential anticancer agents. Oral and Poster presentations. Delgado Y.; Vázquez A.M.; Kowaleff M.; Saxena M.; Torres, Z.; and Tinoco A.D. Experimental Biology Conference, Chicago, IL. April 2017.
Targeted cytochrome c delivery to cancer cells using the transferrin receptor. Poster presentation. Saxena, M.; Delgado, Y.; Sharma, R.K.; Sharma, S.; Guzmán, S.P.; Tinoco, A.D.; Griebenow, K.H. 253rd American Chemical Society, National Meeting & Exposition, San Francisco, CA. 2-6 April 2017.
Ribonucleotide reductase enzyme a target for Titanium complexes: A strategy to cure cancer. Poster presentation. Gaur, K.; Pérez, S.M.; Akam, E.; Tomat, E.; Saxena, M.; Sharma, R.K.; Tinoco, A.D., 253rd American Chemical Society, National Meeting & Exposition, San Francisco, CA. 2-6 April 2017.
The role of citrate and transferrin in determining Ti(IV) solubility, bioavailability, and its regulation. Poster presentation. Sharma, S.; Saxena, M.; Tinoco, A.D., 253rd American Chemical Society, National Meeting & Exposition, San Francisco, CA. 2-6 April 2017.
Intracellular tracing of deferasirox and its Ti(IV) complex by the FITC probe to study their cytotoxic mechanism of action. Oral presentation. Kowaleff, M.; Delgado, Y.; Tinoco, A.D. 253rd American Chemical Society National Meeting & Exposition, Oral presentation, San Francisco, CA. 2-6 April 2017.
Synthesis and Biological Evaluation of α-Methoxylated Acetylenic Fatty Acids. Oral presentation. Morales, C.; Álvarez, E.; Torres, Z.; Delgado, Y.; Tinoco, A. D.; Balaña Fouce, R.; Carballeira, N. M. 253rd American Chemical Society National Meeting & Exposition, Oral presentation, San Francisco, CA. 2-6 April 2017.
Elucidating titanium(IV) inhibition of cellular iron(III) dependence as an anticancer drug design strategy. Poster presentation. Pérez Otero, S.; Tinoco, A.D. INBRE External Advisory Committee Meeting, Dorado, PR. March 2017.
Ti(IV) Bound Transferrin X-ray Crystal Structure Reveals Citrate’s Synergistic Role in Ti-Transferrin Binding. Poster presentation. Saxena, M.; Sharma, S.; Noinaj, N.; and Tinoco, A.D. 4th Annual BioXFEL conference at Hotel Caesars Palace, Las Vegas, NV, USA. 10-12 January, 2017.
Targeted cytochrome c delivery to cancer cells using the transferrin receptor. Poster presentation. Saxena, M.; Delgado, Y.; Sharma, R.K.; Sharma, S.; Guzmán, S.P.; Tinoco, A.D.; Griebenow, K.H. Cell Biology 2016 ASCB Annual Meeting, San Francisco, CA. December 2016.
Determination of Ti(IV) metallome in the cellular environment and its utility in the designing of the anticancer drugs. Poster presentation. Gaur, K.; Tinoco, A.D. Casa Abierta Programas Graduados, Faculty of Natural Sciences, Universidad de Puerto Rico, Río Piedras, PR. 21 October 2016.
Expanding the therapeutic potential of deferasirox in Ti(IV) anticancer drug design. Poster presentation. Loza-Rosas, S.A. V Latin American Meeting on Biological Inorganic Chemistry. Querétaro, México. October 2016.
Elucidating titanium(IV) inhibition of cellular iron(III) dependence as an anticancer drug design strategy. Oral presentation. Pérez Otero, S.; Tinoco, A.D. Gulf Coast Undergraduate Research Symposium, Rice University, Houston, Texas. October 2016.
Cell death pathways induced by Titanium(IV) Deferasirox as potential anticancer complex. Delgado Y.; Vázquez A.M.; Kowaleff, M.; Saxena, M.; Torres, Z.; and Tinoco, A.D. Poster presentation. Forward Research & Innovation Summit, San Juan, PR. September 2016.
Exploring the strategies to find effective delivery vehicles for Ti(IV) compounds. Pandrala, M.; Parham, L.R.; Casañas-Montes, B.; and Tinoco, A.D. Poster presentation. Forward Research & Innovation Summit, San Juan, PR. September 2016.
Synergism of citrate and transferrin revealing Ti-Tf binding, transport and regulation. Quiñones González, E.P.; Tinoco, A.D. Poster presentation. 51ST ACS PR CHEM 2016, San Juan, PR. August 2016.
Undergraduate research as a fundamental mechanism towards a higher education: Research Experience for Undergraduates PR-CLIMB. Poster presentation. Cruz-Galarza, Y.M.; Fuentes-Vergara, C.; Tinoco, A.D. 2016 Biennial Conference on Chemical Education, Poster presentation, University of Northern Colorado. July 2016.